Corrigendum to “Disruption of the potassium channel regulatory subunit KCNE2 causes iron-deficient anemia” [Experimental Hematology, Vol. 42, Issue 12, p1053–1058.e1]
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چکیده
Corrigendum to ‘‘Disruption of the potassium channel regulatory subunit KCNE2 causes iron-deficient anemia’’ [Experimental Hematology, Vol. 42, Issue 12, p1053–1058.e1] Grace Salsbury, Emma L. Cambridge, Zoe McIntyre, Mark J. Arends, Natasha A. Karp, Christopher Isherwood, Carl Shannon, Yvette Hooks, The Sanger Mouse Genetics Project, Ramiro Ramirez-Solis, David J. Adams, Jacqueline K. White, and Anneliese O. Speak Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire, United Kingdom; University of Edinburgh Division of Pathology, Institute of Genetics & Molecular Medicine, Western General Hospital, Edinburgh, United Kingdom
منابع مشابه
Disruption of the potassium channel regulatory subunit KCNE2 causes iron-deficient anemia
Iron homeostasis is a dynamic process that is tightly controlled to balance iron uptake, storage, and export. Reduction of dietary iron from the ferric to the ferrous form is required for uptake by solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2 (Slc11a2) into the enterocytes. Both processes are proton dependent and have led to the suggestion of the importanc...
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Nonalcoholic fatty liver disease (NAFLD) is an increasing health problem worldwide, with genetic, epigenetic, and environmental components. Here, we describe the first example of NAFLD caused by genetic disruption of a mammalian potassium channel subunit. Mice with germline deletion of the KCNE2 potassium channel β subunit exhibited NAFLD as early as postnatal day 7. Using mouse genetics, histo...
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BACKGROUND Sudden cardiac death (SCD) is the leading global cause of mortality, exhibiting increased incidence in patients with diabetes mellitus. Ion channel gene perturbations provide a well-established ventricular arrhythmogenic substrate for SCD. However, most arrhythmia-susceptibility genes, including the KCNE2 K(+) channel β subunit, are expressed in multiple tissues, suggesting potential...
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Gastric cancer is the second leading cause of cancer death worldwide. Predisposing factors include achlorhydria, Helicobacter pylori infection, oxyntic atrophy and TFF2-expressing metaplasia. In parietal cells, apical potassium channels comprising the KCNQ1 alpha subunit and the KCNE2 beta subunit provide a K(+) efflux current to facilitate gastric acid secretion by the apical H(+)K(+)ATPase. A...
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Gastric cancer (GC) is one of the most common cancers worldwide. Among GC patients the mortality rate remains high-most are diagnosed at advanced disease stages due to the lack of symptoms in early disease. Prominent risk factors include age, male sex, smoking, radiation, H. pylori colonization, and a positive family history. Depending on tumor staging, treatment consists of neoadjuvant, adjuva...
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